Long-range movement and fibril association of type X collagen within embryonic cartilage matrix.

نویسندگان

  • Q A Chen
  • E Gibney
  • J M Fitch
  • C Linsenmayer
  • T M Schmid
  • T F Linsenmayer
چکیده

A recent immunoelectron microscopic study of type X collagen in developing cartilage gave results that could be explained by movement of the molecule from one region of the cartilage matrix to another, there becoming associated with preexisting collagen fibrils. In the present study, to test the feasibility of this model we incubated pieces of nonhypertrophic, embryonic chicken sternal cartilage (which has no endogenous type X collagen) in medium with type X collagen and then used immunofluorescence and immunoelectron microscopy to evaluate movement of the molecule through the matrix. The results show that type X collagen molecules can indeed pass through embryonic sternal cartilage matrix and subsequently become fibril-associated.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 87 20  شماره 

صفحات  -

تاریخ انتشار 1990